Key result
Tissue engineering-based valves offer a potential solution to the limitations of traditional mechanical and bioprosthetic pulmonary valves, such as the inability to grow and adapt.
Why the study?
Traditional mechanical and bioprosthetic pulmonary valves cannot grow or adapt to hemodynamic changes, leading to the search for tissue-engineered living valve alternatives.
Do tissue engineering-based valves improve management compared to traditional pulmonary valves in older children and young adults with repaired congenital heart diseases?
Do tissue engineering-based valves improve management compared to traditional pulmonary valves in older children and young adults with repaired congenital heart diseases?
Tissue-engineered pulmonary valves represent a promising paradigm shift for young patients with congenital heart disease by potentially providing a living valve that can grow and adapt, unlike traditional prostheses.
Improved survival in repaired pulmonary valve CHD underscores need for durable valve strategies; leaves open optimal prosthesis selection in young adults.
Prevalence of congenital heart diseases worldwide is around 9 per 1000 newborns, 20% of which affect the pulmonary valve or right ventricular outflow tract. As survival after surgical repair of these defects has improved over time, there is the need to address the long-term issues of older children and young adults with "repaired" congenital heart diseases. In recent decades, the most used types of valves are the mechanical and bioprosthetic valves. Despite improving patients' quality of life, these effects are suboptimal due to their limitations, such as the inability to grow and adapt to hemodynamic changes. These issues have led to the search for living valve solutions through tissue engineering to respond to these challenges. This article aims to review the performance of traditional pulmonary valves and understand how tissue engineering-based valves can improve the management of these patients.
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Almeida-Pinto et al. (2022) conducted a review in Congenital heart diseases affecting the pulmonary valve or right ventricular outflow tract. Tissue engineering-based pulmonary valves vs. Traditional pulmonary valves (mechanical and bioprosthetic) was evaluated. Tissue engineering-based valves offer a potential solution to the limitations of traditional mechanical and bioprosthetic pulmonary valves, such as the inability to grow and adapt.
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