Key result
Intravenous adenosine caused bronchoconstriction in 2 out of 26 treated patients, both of whom were the only patients with asthma in the cohort.
Why the study?
Does intravenous adenosine induce bronchospasm in patients with asthma?
Observational (n=26)
Does intravenous adenosine induce bronchospasm in patients with asthma?
Intravenous adenosine can induce prolonged bronchospasm in asthmatic patients, suggesting alternative treatments for supraventricular tachycardia should be considered in this population.
May warrant caution with adenosine in asthmatics; leaves open need for larger trials.
Adenosine is well known to cause bronchoconstriction when inhaled, but to date, there has been only one report following the intravenous route. 2. Adenosine caused bronchoconstriction in two patients (the only two with asthma) out of 26 treated with the drug. In one subject the duration of response was much longer than previously reported following inhalation. 3. We suggest that adenosine may aggravate bronchospasm in some asthmatics and alternative treatments for supraventricular tachycardia should be considered in this group.
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Drake et al. (1994) conducted an observational in Supraventricular tachycardia (n=26). Intravenous Adenosine was evaluated on Bronchoconstriction. Intravenous adenosine caused bronchoconstriction in 2 out of 26 treated patients, both of whom were the only patients with asthma in the cohort.
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