Key result
Abdominal aortic aneurysms show marked upregulation of MMP-3 and TIMP-3 over occlusive disease.
Why the study?
The role of matrix metalloproteinases and their inhibitors in the pathogenesis of abdominal aortic aneurysm compared to aortic occlusive disease was unclear.
Population
8 patients with AAA and 8 patients with AOD
Comparison
AAA aortic wall vs AOD aortic wall
Design
Observational study using reverse-transcriptase polymerase chain reaction
Authors
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Suggests distinct matrix remodeling in AAA; hypothesis-generating and should not yet change practice.
Observational (n=16)
Absolute Event Rate: -1.9% vs -4%
p-value: p=<0.005
Carrell et al. (2002) conducted an observational in Abdominal aortic aneurysm and aortic occlusive disease (n=16). Abdominal aortic aneurysm (AAA) vs. Aortic occlusive disease (AOD) was evaluated on Stromelysin-1 (MMP-3) mRNA expression (mean log10 ratio) (p=<0.005). Abdominal aortic aneurysm walls expressed significantly higher levels of stromelysin-1 (MMP-3) and TIMP-3 compared to aortic occlusive disease walls (P<0.005 and P<0.01, respectively).
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