Comparative Study of Influence of General Anaesthesia Alone versus General Anaesthesia with Magnesium Sulfate on Post-Operative Inflammatory Biomarkers after Elective Abdominal Hysterectomy

Background: As the second most common intracellular cation, behind potassium, enzyme activities in humans depend on magnesium. This study examined the effects of three blood inflammatory biomarkers—C-reactive protein, interleukin 6, and procalcitonin—after an elective abdominal hysterectomy between a general anesthetic alone and a general anesthesia supplemented with magnesium sulphate. Methods: This randomized controlled study included forty patients who chose to have a general anesthesia for their abdominal hysterectomy. Group 1 patients were all given general anesthesia. Under the influence of general anesthesia, patients in Group 2 received magnesium sulfate. There was a significant difference in IL6 levels between the groups given general anesthesia and those given MgSO4 at 1 and 4 hours postoperatively (P value < 0.001). On the first and fourth hours after surgery, the procalcitonin levels of the MgSO4 group were noticeably lower than those of the general anesthetic group (p < 0.001, respectively). Furthermore, the MgSO4 group showed a significantly reduced CRP level four hours after the procedure, in contrast to the group that had general anesthesia (P value < 0.001). In all groups, there was a link between the level of interleukin-6 at 4 hours and the duration of the surgical procedure (p value 0.001 and <0.001 in group I and group II respectively), indicating that the surgery may have been more complex. End result: When magnesium sulphate was administered in addition to general anesthesia after an elective abdominal hysterectomy and procalcitonin were much lower than when general anesthetic was administered alone.