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July 5, 2026Journal of the American Society for Mass Spectrometry

How “Soft” Are Your Gas Mixtures? Effects of Modifier Gas Types on the Dissociation of Labile Ions in Differential Mobility Spectrometry

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Authors

AFA. FinlayWGWojciech GabryelskiWHW. Scott Hopkins

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Overview

Randomized trial investigates the impact of gas mixtures on ion dissociation in DMS, suggesting a method for predicting ion stability.

Key Points

  • The research aims to understand how different modifier gases affect the stability of labile ions in differential mobility spectrometry.
  • Investigated effects of carrier gas mixtures on thermometer ions and protonated glycine in DMS.
  • Measured effective temperature (T eff ) changes with added CO 2 and various modifier gases.
  • Analyzed the correlation between separation voltage and gas mixture viscosity on ion dissociation.
  • Every 10% addition of CO 2 lowered T eff by 5 K; the inflection point of the survival yield curve varied with gas type.
  • Critical separation voltage (SV crit) correlated strongly with gas viscosity.
  • A new approximation model for correlating SV crit with gas viscosity was proposed, improving prediction accuracy.

Cite This Study

Finlay et al. (2026) studied this question.

synapsesocial.com/papers/6a49f3b0f5d1d45b287ffb63https://doi.org/10.1021/jasms.6c00084
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