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July 2, 2026Journal of Functional FoodsOpen Access

Nostoc commune Vaucher polysaccharide alleviates cyclophosphamide-induced immunosuppression and intestinal injury by modulating gut microbiota and associated metabolites

Ying Pan Mingjie Hu Haoran Qi Han Wang Yanzhuo Liu Zi Wang Liankui Wen Xinyao Liu Xuesheng Hu

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Key Points

The aim is to explore how Nostoc commune Vaucher polysaccharides (NCEP) influence immune function and gut health by modulating microbiota and metabolites.
NCEP administered to cyclophosphamide-induced immunosuppressive mice
Evaluation of changes in gut microbiota and metabolites
Use of non-targeted metabolomics to analyze metabolic pathways
NCEP treatment improved antioxidant enzyme activity and reversed intestinal mucosa damage in mice
NCEP altered the composition of gut microbiota and increased short-chain fatty acid production
Non-targeted metabolomics indicated significant changes in Type I polyketide and Phenazine biosynthesis pathways

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Implication

Examines NCEP's effects on gut microbiota and intestinal health in immunosuppressed mice, suggesting potential for food applications.

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Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a49f411f5d1d45b287ffc10 https://doi.org/10.1016/j.jff.2026.107418

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