Key result
Cognitive impairment affects ~14% of older anticoagulated AF patients annually, predicted by vascular risk factors.
Why the study?
Longitudinal studies providing specific incidence rates and clinical predictors of cognitive decline in older anticoagulated AF patients were lacking.
Cohort (n=140)
No
Older patients with atrial fibrillation on oral anticoagulants experience a high incidence of cognitive decline, which is independently predicted by vascular comorbidities such as coronary heart disease, prior stroke, and diabetes.
High cognitive impairment rates in older AF patients on OACs with vascular comorbidities warrant monitoring; hypothesis-generating for prevention trials.
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Carlo et al. (2026) conducted a cohort in Atrial fibrillation (n=140). Atrial fibrillation on oral anticoagulants was evaluated on Incident cognitive impairment (cases per 1000 person-years) (95% CI 94.4-199.6). Older atrial fibrillation patients on oral anticoagulants had a cognitive impairment incidence of 139.9 per 1000 person-years, independently predicted by coronary heart disease, stroke, and diabetes.
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