PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
July 5, 2026American Journal of Case Reports0 citationsOpen Access

Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review

TOTanya OdishoSESedighe EsmaeilzadeALAlexander Laskaris

Key Result

A 54-year-old man developed a high-grade undifferentiated pleomorphic sarcoma in the neck 22 years after receiving 59.4 Gy of external beam radiation therapy for medullary thyroid carcinoma.

Key Points

  • To discuss the occurrence of undifferentiated pleomorphic sarcoma in the neck after radiation therapy for medullary thyroid carcinoma.
  • Conducted a case report detailing the patient's history and subsequent diagnosis of sarcoma.
  • Reviewed existing literature on radiation-induced sarcomas associated with thyroid cancer treatments.
  • The patient developed undifferentiated pleomorphic sarcoma 20 years post external beam radiation.
  • A total of 4 similar cases were noted in the literature review, indicating a potential link between radiation and sarcoma.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 54-year-old man who developed a high-grade undifferentiated pleomorphic sarcoma in the neck 22 years after receiving external beam radiation therapy for medullary thyroid carcinoma.

Case report of radiation-associated undifferentiated pleomorphic sarcoma of the neck occurring 2 decades after external beam radiation for medullary thyroid carcinoma.

Limitations

  • Single case report limits generalizability
  • Distorted anatomy from prior surgery and radiation limited imaging interpretation
  • Inability to achieve negative surgical margins due to prior radiation and surgery

Abstract

Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review - Article abstract #953580

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Odisho et al. (2026) conducted a case report in Radiation-associated undifferentiated pleomorphic sarcoma (n=1). External beam radiation therapy was evaluated on Development of radiation-associated sarcoma. A 54-year-old man developed a high-grade undifferentiated pleomorphic sarcoma in the neck 22 years after receiving 59.4 Gy of external beam radiation therapy for medullary thyroid carcinoma.

synapsesocial.com/papers/6a49f591f5d1d45b28800544https://doi.org/10.12659/ajcr.953580
Ask AI
Helpful
Bookmark
Share
View Full Paper