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This comment aims to address the comparative analysis of botulinum toxin A formulations without complexing proteins.

July 5, 2026ToxinsOpen Access

Comment on Honndorf et al. Comparative Analytics and Pharmacodynamics of the Complex Protein-Free Botulinum Toxin Type A Formulations DaxibotulinumtoxinA, IncobotulinumtoxinA and RelabotulinumtoxinA. Toxins 2026, 18, 142

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This comment aims to address the comparative analysis of botulinum toxin A formulations without complexing proteins.
Evaluation of the pharmacodynamics of DaxibotulinumtoxinA, IncobotulinumtoxinA, and RelabotulinumtoxinA.
Comparison of the clinical efficacy and safety profiles among the formulations.
DaxibotulinumtoxinA showed a distinct pharmacodynamic profile compared to IncobotulinumtoxinA and RelabotulinumtoxinA.
Key differences in formulation impact clinical outcomes, emphasizing the need for tailored therapeutic strategies.

Comment discusses the pharmacodynamics of three botulinum toxin A products, highlighting formulation differences.

In their recent paper comparing three complexing protein-free botulinum toxin A products available on the market [...]

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Ståhl et al. (2026) studied this question.

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Comment discusses the pharmacodynamics of three botulinum toxin A products, highlighting formulation differences.

In their recent paper comparing three complexing protein-free botulinum toxin A products available on the market [...]