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July 5, 2026International Journal of OncologyOpen Access

PDLIM2 acts as a central regulator of ubiquitination, immune signaling, and mitochondrial metabolism in lung cancer suppression (Review)

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Authors

TCTsung‐Hsien ChuangJGJeng-Hung GuoJYJing-Xing Yang

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Overview

Review shows PDLIM2 as a tumor suppressor in lung cancer, suggesting its potential as a therapeutic target.

Key Points

  • This review aims to highlight the role of PDLIM2 in lung cancer suppression and its potential as a therapeutic target.
  • Analysis of clinical, genetic, and experimental evidence regarding PDLIM2's role in lung cancer.
  • Examination of the mechanistic pathways involving PDLIM2, including ubiquitination and immune signaling.
  • Discussion of the impact of PDLIM2 on mitochondrial metabolism and tumor growth.
  • PDLIM2 is downregulated in most lung tumors, correlating with poor prognostic outcomes.
  • Restoration of PDLIM2 suppresses lung tumor growth and enhances chemosensitivity.
  • PDLIM2 influences immune responses, particularly in relation to immune checkpoint inhibitors.

Cite This Study

Chuang et al. (2026) studied this question.

synapsesocial.com/papers/6a49f68df5d1d45b28800daahttps://doi.org/10.3892/ijo.2026.5909
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation2024 · 8 citations
  2. 2PDLIM2 in Lung Adenocarcinoma Metastasis2025
  3. 3PDLIM2 in lung adenocarcinoma metastasis2026
  4. 4Exploring PDLIM2 as a prognostic biomarker and therapeutic target in lung adenocarcinoma2026
  5. 5Abstract 4746: Downregulation of PDLIM2 promotes tumor growth through regulation of oncometabolites and HIF-1α pathway2026