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July 5, 2026Critical Reviews in Toxicology

Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology

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Authors

SKSyed Shabi Ul Hassan KazmiSBSyeda Mutyyeba BatoolPPPaolo Pastorino

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Overview

Systematic review reveals microplastic distribution in maternal-fetal system impacting developmental biology.

Key Points

  • This review aims to explore the mechanisms and characteristics of microplastic trafficking in the maternal-fetal system.
  • Conducted a systematic review across six biological matrices: placenta, breast milk, endometrium, amniotic fluid, meconium, and feces.
  • Used multivariate modeling to analyze size-dependent transport and particle characteristics.
  • Quantitatively profiled microplastic burden and identified tissue-specific signatures.
  • Placental samples showed a 2.3-fold higher fragment proportion with polypropylene dominance (p<0.05).
  • Endometrial tissues indicated significant microplastic accumulation, suggesting potential intergenerational implications.
  • Distinct polymer clustering was observed, with PA/PU in breast milk and PET/PC in amniotic fluid, indicating differential exposure.

Cite This Study

Kazmi et al. (2026) studied this question.

synapsesocial.com/papers/6a49f68df5d1d45b28800e46https://doi.org/10.1080/10408444.2026.2692120
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