Demonstrates visible-light-driven phosphonylation of secondary amines, suggesting a new pathway for drug modifications.
We report N -phenylbenzo[ c ]phenothiazine ( PTZ-6 ), an organic small-molecule photocatalyst, which enables a general, metal-free, visible-light-driven Arbuzov-type α-C(sp 3 )–H phosphonylation of diverse cyclic and acyclic secondary amines via an intramolecular 1,5-hydrogen-atom-transfer (HAT) manifold. The protocol exhibits broad functional-group tolerance and is amenable to late-stage modification of structurally complex drugs and bioactive molecules.
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Qiao et al. (2026) studied this question.
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