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Case study reveals that mystical experiences in ketamine-assisted psychotherapy improve therapeutic outcomes, suggesting valuable integration of subjective effects.
This case study explores the potential role of mystical-type experiences in ketamine-assisted psychotherapy (KAP). A patient with generalized anxiety disorder and migraines underwent four intramuscular KAP sessions (0.5-0.9 mg/kg). Outcomes were assessed using the Outcome Questionnaire-45 (OQ-45), the Hood Mysticism Scale (HMS), and interviews. Greater therapeutic gains followed sessions with higher HMS scores. The patient attributed improvements to the psychological and spiritual impact of the experiences, emphasizing the therapeutic relationship and integration process. In this case, these experiences appeared to play a meaningful role in therapeutic change, contributing to the discussion on the role of subjective effects in KAP.
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Couceiro et al. (2026) studied this question.
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