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This research aims to characterize a novel HIV-1 circulating recombinant form observed in Yunnan Province, China.

Identification of a Complex HIV-1 Circulating Recombinant Form (CRF203_cpx) Originating from Three Main Circulating Recombinant Forms in China

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Randomized trial identifies new HIV-1 recombinant form in China, suggesting complex evolutionary dynamics.

This research aims to characterize a novel HIV-1 circulating recombinant form observed in Yunnan Province, China.
Obtained near-full-length genome sequences from three individuals infected via heterosexual contact.
Conducted Bayesian Markov chain Monte Carlo analysis to determine the emergence timeline.
Classified the genome into 14 subregions derived from three known CRFs.
CRF203_cpx was identified as a complex CRF, comprising segments from CRF55_01B, CRF07_BC, and CRF01_AE.
The strain emerged between 2018 and 2021, revealing a distinct monophyletic clade.
This is the first definitive identification of a complex CRF involving three separate CRFs in China.

Chen et al. (2026) studied this question.

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