Key result
Rhinovirus infection inhibited nuclear import and caused the degradation of nuclear pore complex components Nup153 and p62, resulting in the cytoplasmic accumulation of nuclear proteins.
Rhinovirus inhibits nuclear import and degrades NPC components, suggesting a common picornavirus strategy to evade host immune defenses and accumulate nuclear proteins in the cytoplasm.
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May indicate conserved picornavirus immune evasion; hypothesis-generating with no current clinical implications.
Gustin et al. (2002) studied Rhinovirus infection. Rhinovirus type 14 infection vs. Mock infection was evaluated on Nuclear import activity and degradation of NPC components (Nup153 and p62). Rhinovirus infection inhibited nuclear import and caused the degradation of nuclear pore complex components Nup153 and p62, resulting in the cytoplasmic accumulation of nuclear proteins.
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