September 1, 1997Journal of VirologyOpen Access

Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro

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Structured PICO

Population

In vitro models (eukaryotic cells, poliovirus-infected HeLa cells)

Intervention

Poliovirus-encoded protease 2APro

Outcome

Cleavage of TATA-binding protein (TBP) and inhibition of RNA polymerase II transcriptionsurrogate

Poliovirus protease 2APro cleaves TBP but does not directly inhibit RNA polymerase II transcription, indicating that transcriptional inhibition is secondary to translational shutoff.

Authors

PYPriyanka YalamanchiliRutgers, The State University of New Jersey RBRamanuj BanerjeeIndian Institute of Technology Kanpur ADAmitava DasguptaUniversity of Kansas Medical Center

Discussion

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Implication

2APro cleavage of TBP does not directly inhibit transcription; leaves open indirect mechanisms of poliovirus host shutoff in animal models.

Cite This Study

Yalamanchili et al. (1997) studied this question.

synapsesocial.com/papers/6a83446ecfe08b7fa662d575 https://doi.org/10.1128/jvi.71.9.6881-6886.1997

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Implication

2APro cleavage of TBP does not directly inhibit transcription; leaves open indirect mechanisms of poliovirus host shutoff in animal models.

Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro

Structured PICO

Discussion

Implication

Cite This Study

Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider