May 1, 1996Journal of VirologyOpen Access

Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro

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Population

HeLa cell extracts (poliovirus-infected and uninfected) and purified TATA-binding protein (TBP)

Comparison

Poliovirus infection or purified recombinant… vs Uninfected or mock-infected HeLa cell extracts

Design

Preclinical

Authors

Discussion

Does not alter poliovirus management; extends mechanistic insights in animal models but leaves open human translation and therapeutic targeting.

Population

HeLa cell extracts (poliovirus-infected and uninfected) and purified TATA-binding protein (TBP)

Intervention

Poliovirus infection or purified recombinant poliovirus protease 3Cpro

Comparator

Uninfected or mock-infected HeLa cell extracts

Outcome

Inhibition of RNA polymerase II-mediated basal transcription and TBP binding to TATA sequencesurrogate

Poliovirus infection inhibits host cell RNA polymerase II transcription through the viral protease 3Cpro, which inactivates the TATA-binding protein.

Yalamanchili et al. (1996) studied this question.

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Does not alter poliovirus management; extends mechanistic insights in animal models but leaves open human translation and therapeutic targeting.