Population
Escherichia coli expressing poliovirus 2A protease, rabbit reticulocyte lysates, and synthetic peptides
Design
Preclinical
Authors
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May accelerate 2A protease inhibitor screening; leaves open cellular and in vivo validation for antiviral use.
The study demonstrates the successful expression of active poliovirus 2A protease in E. coli and characterizes its cis- and trans-cleavage activities, including the development of a rapid cleavage assay.
Alvey et al. (1991) studied this question.
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