Population
COS-1 cells and reconstituted polioviruses
Design
Preclinical
Authors
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No immediate clinical implications; extends prior cell-based observations on 2Apro mechanisms but leaves open in vivo relevance.
Poliovirus 2Apro inhibits host cell gene expression through distinct mechanisms at both the transcriptional and translational levels.
Ventoso et al. (1998) studied this question.
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