Population
COS cells infected with a recombinant vaccinia virus bearing phage T7 RNA polymerase
Design
Preclinical
Follow-up
up to 20-25 hours post infection
Authors
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Correlates 2A(pro)-mediated p220 cleavage with translation shutoff; hypothesis-generating for eIF-4F in viral infections, needs in vivo confirmation.
Transient expression of poliovirus 2A(pro) in COS cells causes p220 cleavage and inhibits translation from newly made mRNAs, providing insights into eIF-4F function.
Feduchi et al. (1995) studied this question.
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