Population
Recombinant vaccinia virus expressing poliovirus coat precursor protein P1 fused to truncated 2A proteinase
Comparison
Coinfection with poliovirus type 1, 2, or 3 or… vs Coinfection with encephalomyocarditis virus…
Design
Preclinical
Authors
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Functional 2A blocks vaccinia recombinants; leaves open whether 2A ablation enables stable viral vector engineering.
Expression of functional poliovirus proteinase 2A prevents the isolation of vaccinia virus recombinants, likely due to its role in translational inhibition.
Jewell et al. (1990) studied this question.
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