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September 2, 1994Science

Engineering poliovirus as a vaccine vector for the expression of diverse antigens

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Population

Infected cells and animals (preclinical model)

Design

Preclinical

Authors

RARaul AndinoLawrence Livermore National LaboratoryDSDeborah SilveraNew York UniversitySSS. SuggettUniversity of California, San Francisco

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Implication

Poliovirus may serve as a vaccine vector in animals; hypothesis-generating and should not yet change clinical practice.

Structured PICO

P
Population
Infected cells and animals (preclinical model)
I
Intervention
Poliovirus recombinants constructed by fusing exogenous peptides (up to 400 amino acids) and an artificial cleavage site for viral protease 3Cpro to the amino terminus of the viral polyprotein
O
Outcome
Viral replication, polyprotein production and processing, retention of exogenous sequences, and humoral immune responsesurrogate

Poliovirus can be engineered as a vaccine vector capable of expressing diverse exogenous antigens and eliciting a humoral immune response.

Cite This Study

Andino et al. (1994) studied this question.

synapsesocial.com/papers/6a7d7a172c71273e4183eecfhttps://doi.org/10.1126/science.8073288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis1990 · 381 citations
  2. 2An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis1988 · 173 citations
  3. 3Modelling of poliovirus1990 · 21 citations
  4. 4Poliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 11992 · 49 citations
  5. 5Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.1982 · 310 citations