Key result
Melperone and thiothixene both significantly reduced psychotic morbidity with no significant difference between groups, but melperone was associated with fewer extrapyramidal side effects.
Why the study?
Does melperone improve clinical outcomes or reduce side effects compared to thiothixene in women with schizophrenia?
RCT (n=81)
Double-blind
Does melperone improve clinical outcomes or reduce side effects compared to thiothixene in women with schizophrenia?
Melperone is as effective as thiothixene in reducing psychotic morbidity in women with schizophrenia, but with fewer extrapyramidal side effects and less impact on dopaminergic variables.
Answers are grounded in this paper and cite their sources.
Melperone matches thiothixene efficacy with fewer EPS; supports its preference in EPS-prone schizophrenia patients.
Eighty-one women with psychosis of schizophrenic or paranoid type participated in a double-blind comparison of melperone (300 mg daily) and thiothixene (30 mg daily). The purpose of the study was to analyse clinical and biochemical effects of the drugs. Both treatments were associated with significant reductions in psychotic morbidity. No significant difference in the clinical ratings was found between the drugs. However, there were more extrapyramidal side effects in the thiothixene as compared to the melperone group. Biochemically, the dopaminergic variables HVA in CSF and prolactin in plasma and CSF showed significantly greater elevations in the thiothixene group.
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L. Bjerkenstedt (1989) conducted an RCT in Psychosis of schizophrenic or paranoid type (n=81). Melperone vs. Thiothixene (30 mg daily) was evaluated on Clinical ratings of psychotic morbidity. Melperone and thiothixene both significantly reduced psychotic morbidity with no significant difference between groups, but melperone was associated with fewer extrapyramidal side effects.
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