Key result
Haloperidol and thioridazine showed few clinical differences in restless mentally subnormal patients, though serum cholesterol was higher after thioridazine than haloperidol (P<0.05).
Why the study?
Do haloperidol and thioridazine improve clinical symptoms and how do they correlate with serum levels in restless mentally subnormal patients compared to placebo?
Population
30 restless mentally subnormal patients
Comparison
Haloperidol and thioridazine vs Placebo (drug holidays)
Design
RCT, Randomized cross-over trial
Authors
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May favor haloperidol to limit cholesterol increases in restless mentally subnormal patients; extends RCT comparisons of these antipsychotics.
RCT (n=30)
Cross-over
Do haloperidol and thioridazine improve clinical symptoms and how do they correlate with serum levels in restless mentally subnormal patients compared to placebo?
In mentally subnormal patients, clinical response to haloperidol and thioridazine correlates poorly with serum drug levels, and thioridazine is associated with higher serum cholesterol.
Väisänen et al. (1981) conducted an RCT in Restless mentally subnormal (n=30). Haloperidol and thioridazine vs. Placebo was evaluated on Clinical response and drug serum levels. Haloperidol and thioridazine showed few clinical differences in restless mentally subnormal patients, though serum cholesterol was higher after thioridazine than haloperidol (P<0.05).
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