November 1, 1996Clinical Pharmacology & Therapeutics

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans

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Why the study?

Does single-dose thioridazine affect ventricular repolarization and blood pressure in healthy male subjects?

Population

9 healthy male subjects

Comparison

Single doses of thioridazine (10 mg and 50 mg) vs Placebo

Design

RCT, randomized-order crossover, double-blind

Follow-up

72 hours after administration

Authors

KHKenneth Hartigan‐GoMercy San Juan Medical Center DBD. Nicholas BatemanUniversity Hospitals of Leicester NHS Trust GNG. NybergSahlgrenska University Hospital

Discussion

Member takes

Implication

Thioridazine warrants QTc and orthostatic BP monitoring; confirms direct repolarization and hemodynamic effects in this RCT.

Structured PICO

Does single-dose thioridazine affect ventricular repolarization and blood pressure in healthy male subjects?

Population

9 healthy male subjects

Intervention

Single doses of thioridazine (10 mg and 50 mg)

Comparator

Placebo

Outcome

Cardiac and other effects (ECG, blood pressure, salivary flow, and psychomotor tests) and their relation to plasma concentration of the parent drug and its principal metabolitessurrogate

Thioridazine exhibits dose-related effects on ventricular repolarization (QTc prolongation) and blood pressure, primarily driven by the parent drug.

Cite This Study

Hartigan‐Go et al. (1996) studied this question.

synapsesocial.com/papers/6a89b577a90c2f4c44fba35e https://doi.org/10.1016/s0009-9236(96)90150-2

View Full Paper

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November 1, 1996Clinical Pharmacology & Therapeutics

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans

View Full Paper

Ask AI

Bookmark

Why the study?

Does single-dose thioridazine affect ventricular repolarization and blood pressure in healthy male subjects?

Population

9 healthy male subjects

Comparison

Single doses of thioridazine (10 mg and 50 mg) vs Placebo

Design

RCT, randomized-order crossover, double-blind

Follow-up

72 hours after administration

Authors

KHKenneth Hartigan‐GoMercy San Juan Medical Center DBD. Nicholas BatemanUniversity Hospitals of Leicester NHS Trust GNG. NybergSahlgrenska University Hospital

Discussion

Member takes

Implication

Thioridazine warrants QTc and orthostatic BP monitoring; confirms direct repolarization and hemodynamic effects in this RCT.

Structured PICO

Does single-dose thioridazine affect ventricular repolarization and blood pressure in healthy male subjects?

Population

9 healthy male subjects

Intervention

Single doses of thioridazine (10 mg and 50 mg)

Comparator

Placebo

Outcome

Cardiac and other effects (ECG, blood pressure, salivary flow, and psychomotor tests) and their relation to plasma concentration of the parent drug and its principal metabolitessurrogate

Thioridazine exhibits dose-related effects on ventricular repolarization (QTc prolongation) and blood pressure, primarily driven by the parent drug.

Cite This Study

Hartigan‐Go et al. (1996) studied this question.

synapsesocial.com/papers/6a89b577a90c2f4c44fba35e https://doi.org/10.1016/s0009-9236(96)90150-2

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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