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September 1, 2005South African Journal of PsychiatryOpen Access

The effects of thioridazine on the QTc interval - cardiovascular safety in a South African setting

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Why the study?

Does thioridazine increase the QTc interval in hospitalised subjects requiring a low-potency antipsychotic?

Population

30 hospitalised subjects in South Africa who required switching from a high-potency to a low-potency…

Comparison

Thioridazine initiated at 300 mg per day vs Baseline (pre-treatment)

Design

Cohort

Follow-up

1 week after initiation and 48 hours after each dose…

Authors

CSC SellerStellenbosch UniversityPOPiet OosthuizenStellenbosch University

Discussion

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Implication

Thioridazine was associated with QTc prolongation in this cohort; supports ECG monitoring but leaves open randomized confirmation of arrhythmic risk.

Structured PICO

Does thioridazine increase the QTc interval in hospitalised subjects requiring a low-potency antipsychotic?

P
Population
30 hospitalised subjects in South Africa who required switching from a high-potency to a low-potency antipsychotic
I
Intervention
Thioridazine initiated at 300 mg per day
C
Comparator
Baseline (pre-treatment)
O
Outcome
Change in QTc interval (determined using Bazett's formula)safety

Thioridazine causes significant QTc prolongation, supporting recommendations against its use as a first-line antipsychotic and highlighting the need for regular ECG monitoring.

Cite This Study

Seller et al. (2005) studied this question.

synapsesocial.com/papers/6a8a577e0f137e402b33839dhttps://doi.org/10.4102/sajpsychiatry.v11i2.97
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of thioridazine hydrochloride and chlorpromazine on the electrocardiogram1966 · 81 citations
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