Catalytic synthesis of pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolins via a cooperative vinylogous anomeric based oxidation using a new H-bond magnetic-MOFs

In this research, Fe 3 O 4 @SiO 2 @NHCO-Zr-MOF was designed and synthesized as a magnetic metal-organic framework (H-bond Magnetic-MOFs based catalyst). This H-bond catalyst was fully characterized by different techniques: FT-IR, SEM, PXRD, EDX, Mapping, N 2 adsorption/desorption (BET/BJH), TGA/DTG and Vibrating sample magnetometry (VSM) proving the structure of the catalyst. A wide range of pyrazolo[3,4- b ]pyridine and pyrazolo[3,4- b ]quinolin derivatives were synthesised using the abovementioned magnetic metal-organic framework, via cooperative vinylogous anomeric-based oxidation (CVABO) with good yields (70–85%). The synthesized compounds were identified using various techniques: melting point, FT-IR, 1 H-NMR and 13 C-NMR. The major advantages are a short reaction time, high efficiency of synthesized products, easy separation of the catalyst, high chemical and thermal stability. Therefore, the present study provides a reasonable and promising approach for the synthesis of porous catalysts with suitable separation capability, especially in organic molecule preparation.