Electrochemical Minisci-type reaction achieves C2-alkylation of N-oxide heteroarenes, indicating new synthetic pathways.
An electrochemical Minisci-type reaction for the regioselective C2-alkylation of N -oxide heteroarenes is reported herein. N -Hydroxyphtalimide redox-active esters were used as primary, secondary, and tertiary alkyl radical precursors. A variety of 2-alkylheterocyclic N -oxides were prepared in the absence of catalyst and exogeneous oxidant. Preliminary mechanistic studies suggested a radical addition pathway via sequential paired electrolysis.
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Djimabi et al. (2026) studied this question.
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