Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction

High Resolution Image Download MS PowerPoint Slide Herein, we report the application of the Ugi four-component reaction as an efficient and versatile strategy for the synthesis of macrocyclic derivatives of monensin. The approach enables the incorporation of a peptidomimetic linker, significantly modulating the biological and cation complexation properties of the obtained compounds. All derivatives were obtained in crystalline form, allowing unambiguous structural elucidation by single-crystal X-ray diffraction, which revealed macrocyclic architectures stabilized by intramolecular hydrogen bonding.