A Deterministic Classification Core with an Agentic Interpretation Layer: An Architecture for Auditable, Human-Gated Clinical Variant Analysis

Vladimir Mitev

doi:10.5281/zenodo.21189570

July 4, 2026Open Access

A Deterministic Classification Core with an Agentic Interpretation Layer: An Architecture for Auditable, Human-Gated Clinical Variant Analysis

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Key Points

The study aims to explore a deterministic approach to AI in clinical variant analysis, emphasizing human oversight for decision-making.
Propose an architecture that separates deterministic decision-making from interpretation by AI agents.
Discuss the role of human oversight at the evidence admissibility stage rather than at the output stage.
Analyze the implications of an agentic AI model in variant classification frameworks.
The proposed architecture ensures that classifications are based on deterministic outputs, maintaining integrity in clinical applications.
Human judgment significantly influences admissibility of evidence in variant classification, enhancing accountability.
Findings suggest that autonomy in AI should not replace human decision-making responsibilities.

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Implication

Examines auditable AI variant classification in clinical settings, suggesting human oversight is crucial.

Abstract

Agentic AI in care delivery is increasingly framed as autonomy with minimal oversight, and recent work places language models inside ACMG/AMP variant classification itself. We argue the opposite for auditable deployment: keep the decision core deterministic and free of model output, confining agents to an interpretation layer acting on already-classified results. Our central, falsifiable claim is that the load-bearing human gate sits upstream, at evidence admissibility, not at output release.

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Cite This Study

Vladimir Mitev (2026) studied this question.

synapsesocial.com/papers/6a4b4641997070ff83b5ba8c https://doi.org/10.5281/zenodo.21189570

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A Deterministic Classification Core with an Agentic Interpretation Layer: An Architecture for Auditable, Human-Gated Clinical Variant Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Deterministic Classification Core with an Agentic Interpretation Layer: An Architecture for Auditable, Human-Gated Clinical Variant Analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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