Key result
Blood-flow-restricted training improves flow-mediated dilatation and VEGF production versus non-restricted training.
Why the study?
Despite growing evidence of the influence of blood-flow-restricted training on body functions, its impact on the vascular system, particularly arteries, remains controversial.
Does blood-flow-restricted training improve arterial functions and angiogenesis in adults compared to non-BFR training?
Meta-Analysis
Does blood-flow-restricted training improve arterial functions and angiogenesis in adults compared to non-BFR training?
p-value: p=0.002
Blood-flow-restricted training significantly improves endothelial function and angiogenesis biomarkers compared to standard exercise, suggesting potential vascular benefits.
Supports inclusion of blood-flow-restricted training in vascular rehabilitation; extends prior exercise evidence to endothelial and angiogenic outcomes.
Despite growing evidence of the significant influence of blood-flow-restricted (BFR) training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of exercise without the restriction of blood flow, influences arterial functions and angiogenesis in adults. Studies comparing the effect of BFR versus non-BFR training on arterial parameters were divided into three categories: endothelial function, angiogenesis, and other vasculature functions. The search was based on Cochrane Library, PubMed®, and Embase, and 38 studies were included. The meta-analysis revealed a more significant improvement in flow-mediated dilatation (FMD) (p = 0.002) and the production of the primary angiogenesis biomarker vascular endothelial growth factor (VEGF) (p = 0.009) after BFR compared to non-BFR training (p = 0.002). The analysis of the pulse wave velocity, ankle-brachial index, systolic blood pressure, and heart rate did not show significant differences in changes between BFR and non-BFR training. The other parameters examined did not have sufficient data to be included in the meta-analysis. The results obtained present trends that suggest significant impacts of BFR training on endothelial functions and angiogenesis. There is still a lack of multicenter randomized clinical trials including many participants, and such studies are necessary to confirm the advantage of BFR over non-BFR activity.
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Maga et al. (2023) reported a meta-analysis. Blood-flow-restricted (BFR) training vs. Non-BFR training was evaluated on Flow-mediated dilatation (FMD) and vascular endothelial growth factor (VEGF) (p=0.002). Blood-flow-restricted training significantly improved flow-mediated dilatation (P=0.002) and vascular endothelial growth factor production (P=0.009) compared to non-restricted training.
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