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August 13, 2019Frontiers in PhysiologyOpen Access

The Effects of Restriction Pressures on the Acute Responses to Blood Flow Restriction Exercise

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Key result

Blood flow restriction exercise at 60% and 80% of limb occlusion pressure induced significant fatigue and metabolic stress compared to low-load exercise without restriction.

Why the study?

Guidelines for selecting restriction pressure during blood flow restriction exercise are lacking, and the acute muscle, metabolic, and cardiopulmonary responses to specific relative restriction pressures remain unclear.

Do different levels of restriction pressure during blood flow restriction exercise affect acute physiological responses?

Population

10 individuals

Comparison

BFRE at 40%, 60%, and 80% LOP vs non-BFRE at 20% MVC vs non-BFRE at 80% MVC

Design

Balanced randomized crossover trial

Authors

MIMichael J. IlettDeakin UniversityTRTimo RantalainenFinnish Institute for Health and WelfareMKMichelle A. KeskeBaker Heart and Diabetes Institute

Discussion

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Implication

Supports ≥60% LOP for effective BFRE responses; extends acute RCT evidence on pressure-dependent fatigue thresholds.

Study Design

Type

RCT (n=10)

Blinding

Open-label

Randomization

Balanced randomized crossover order

Multicenter

No

Structured PICO

Do different levels of restriction pressure during blood flow restriction exercise affect acute physiological responses?

P
Population
10 healthy, relatively sedentary young males who completed five experimental trials of rhythmic isometric knee extension exercise to assess acute physiological responses to blood flow restriction.
I
Intervention
Blood flow restriction exercise (BFRE) at 40%, 60%, and 80% of limb occlusion pressure (LOP) with a workload equivalent to 20% maximal voluntary force (MVC)
C
Comparator
Non-BFRE at 20% MVC (LL) and non-BFRE at 80% MVC (HL)
O
Outcome
Acute muscle, metabolic and cardiopulmonary responses (torque, muscle activity via EMG, tissue oxygenation via near infrared spectroscopy, whole body oxygen consumption, blood lactate and heart rate)surrogate

Main Result

p-value: p=<0.05

A minimum restriction pressure of 60-80% of limb occlusion pressure is recommended to elicit effective acute physiological responses during blood flow restriction exercise.

Limitations

  • Lack of supramaximal stimulation to identify the origin of fatigue (central or peripheral).
  • Use of rhythmic isometric contractions limits extrapolation to more common dynamic BFR exercise training regimens.
  • Lack of direct measurement of limb blood flow.
  • Only male participants were included, reducing generalizability to females.
  • Outcomes of chronic training programs using different levels of applied restriction pressures remain to be tested

Cite This Study

Ilett et al. (2019) conducted an RCT in Healthy, sedentary males (n=10). Blood flow restriction exercise (BFRE) vs. Low-load (20% MVC) and high-load (80% MVC) exercise without blood flow restriction was evaluated on Reduction in maximal voluntary contraction (MVC) torque (fatigue) (p=<0.05). Blood flow restriction exercise at 60% and 80% of limb occlusion pressure induced significant fatigue and metabolic stress compared to low-load exercise without restriction.

synapsesocial.com/papers/6a4c4225028ea97264ab763ehttps://doi.org/10.3389/fphys.2019.01018
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Also Consider

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  1. 1Calculation of Mean Arterial Pressure During Exercise as a Function of Heart Rate.1995 · 97 citations
  2. 2Hemodynamic responses are reduced with aerobic compared with resistance blood flow restriction exercise2017 · 53 citations
  3. 3Influence of continuous or intermittent blood flow restriction on muscle activation during low-intensity multiple sets of resistance exercise2013 · 81 citations
  4. 4Blood Flow Restriction Exercise in Sprinters and Endurance Runners2011 · 48 citations
  5. 5Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction2003 · 254 citations