Key result
Hypertrophic cardiomyopathy was independently correlated with increased carotid arterial stiffness (beta 0.49; 95% CI 1.04-3.02; P<0.001), which in turn correlated with left ventricular filling pressure.
Why the study?
To assess carotid mechanical properties in patients with hypertrophic cardiomyopathy and the relationship between arterial stiffness and left ventricular function in this setting.
Is carotid arterial stiffness increased and related to left ventricular function in patients with hypertrophic cardiomyopathy?
Population
71 patients with hypertrophic cardiomyopathy and 25 normal control subjects
Comparison
Hypertrophic cardiomyopathy with vs without cardiovascular risk factors vs normal controls
Design
Prospective observational study
Authors
Loading...
May identify severe hypertrophic cardiomyopathy phenotypes; leaves open causal links to filling pressure or therapeutic targeting.
Observational (n=96)
Is carotid arterial stiffness increased and related to left ventricular function in patients with hypertrophic cardiomyopathy?
Effect estimate: beta 0.49 (95% CI 1.04-3.02)
p-value: p=<0.001
Carotid arterial stiffness is increased in patients with hypertrophic cardiomyopathy independently of traditional cardiovascular risk factors and correlates with left ventricular filling pressure, suggesting it may be a marker of a more severe phenotype.
Roşca et al. (2019) conducted an observational in Hypertrophic cardiomyopathy (n=96). Hypertrophic cardiomyopathy vs. Healthy controls was evaluated on Carotid arterial stiffness index (β index) (beta 0.49, 95% CI 1.04-3.02, p=<0.001). Hypertrophic cardiomyopathy was independently correlated with increased carotid arterial stiffness (beta 0.49; 95% CI 1.04-3.02; P<0.001), which in turn correlated with left ventricular filling pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: