Key result
Low adiponectin levels in acute Kawasaki disease patients were correlated with severe inflammatory reactions and decreased left ventricular systolic and A myocardial velocities.
Observational (n=53)
Low adiponectin levels in acute Kawasaki disease are associated with severe inflammatory reactions and decreased left ventricular function.
Adiponectin may mark inflammation severity and LV function in acute Kawasaki disease; hypothesis-generating, should not yet change practice.
Purpose : Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-?#6944;lipid profile, and C reactive protein (CRP), and to clarify the association between adiponectin and cardiac function. Methods : Twenty-two KD patients (22 patients in acute phase and 20 patients in subacute phase) were enrolled in the study group. The control group consisted of 31 subjects (13 febrile patients and 18 healthy children). Both groups underwent blood sampling and tissue Doppler imaging (TDI). Results : CRP was significantly increased in the KD group compared with the control group. There were no significant differences in serum TNF-?#6944;IL-6, and adiponectin levels between groups. However, a negative correlation was found between adiponectin level and CRP level or platelet count. Systolic myocardial velocity and A myocardial velocity measured by TDI were decreased significantly in the acute KD group compared with the subacute KD group and control group. Positive correlations were found between adiponectin level and systolic myocardial velocity or A myocardial velocity. Conclusion : In acute KD patients, low adiponectin level was related to severe inflammatory reactions and decreased left ventricular functions.
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Ahn et al. (2010) conducted an observational in Kawasaki disease (n=53). Kawasaki disease vs. Febrile patients and healthy children was evaluated on Serum adiponectin, TNF-α, IL-6 levels, and cardiac function parameters. Low adiponectin levels in acute Kawasaki disease patients were correlated with severe inflammatory reactions and decreased left ventricular systolic and A myocardial velocities.
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