Key result
Significant linkage of QTc was found with the loci for LQT1 on chromosome 11 and LQT4 on chromosome 4, but not LQT2, LQT3, or LQT5, in 66 pairs of normal dizygotic twins and their parents.
Why the study?
Are variations in known long-QT syndrome loci linked to the QTc interval in normal subjects?
Population
66 pairs of unselected normal dizygotic (DZ) twin subjects and their parents
Design
Cross-sectional
Authors
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QTc linkage to LQT1/LQT4 loci in healthy subjects is hypothesis-generating; leaves open whether these variants influence arrhythmia risk in the general population.
Observational
Are variations in known long-QT syndrome loci linked to the QTc interval in normal subjects?
Quantitative trait loci for LQT1 and LQT4 are linked to the QTc interval in normal subjects, suggesting genetic variations at these loci may influence arrhythmia risk in the general population.
Busjahn et al. (1999) conducted an observational in Normal subjects. LQT gene loci variations was evaluated on Linkage of QTc with LQT gene loci. Significant linkage of QTc was found with the loci for LQT1 on chromosome 11 and LQT4 on chromosome 4, but not LQT2, LQT3, or LQT5, in 66 pairs of normal dizygotic twins and their parents.
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