Why the study?
Does the Ile164 beta2-adrenergic receptor polymorphism worsen the outcome of death or cardiac transplantation in patients with NYHA class II-IV heart failure?
Population
259 patients with NYHA functional class II-IV heart failure due to ischemic or dilated cardiomyopathy, and…
Comparison
Presence of the Ile164 beta2-adrenergic receptor… vs Wild-type Thr at position 164 of the…
Design
Cohort
Follow-up
1 year
Authors
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Ile164 polymorphism linked to markedly worse HF outcomes; leaves open role in risk stratification or genotype-guided trials.
Does the Ile164 beta2-adrenergic receptor polymorphism worsen the outcome of death or cardiac transplantation in patients with NYHA class II-IV heart failure?
The Ile164 beta2-adrenergic receptor polymorphism is associated with significantly worse survival and higher rates of cardiac transplantation in patients with heart failure.
Liggett et al. (1998) studied this question.
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