Key result
Phenotyping of the murine BXD genetic reference population identified several QTLs and candidate genes significantly associated with cardiac hypertrophy, ventricular dilation, and systolic function.
Why the study?
The study aimed to establish a cardiac phenotype-genotype correlation in a murine genetic reference population of BXD RI strains by associating echocardiography, blood pressure, and cardiomyocyte diameter traits with genetic background.
Establishes cardiac phenotype-genotype link in BXD strains, indicating potential genetic factors in heart function.
This study aimed to establish a cardiac phenotype-genotype correlation in murine genetic reference population of BXD RI strains by phenotyping the echocardiography, blood pressure, and cardiomyocyte diameter traits and associating each collected phenotype with genetic background. Our study identified several QTLs and candidate genes that have significant association with cardiac hypertrophy, ventricular dilation, and function including systolic hyperfunction and dysfunction.
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Orgil et al. (2022) studied this question. Genetic background (BXD RI strains) was evaluated on Cardiac phenotype-genotype correlation (echocardiography, blood pressure, and cardiomyocyte diameter traits). Phenotyping of the murine BXD genetic reference population identified several QTLs and candidate genes significantly associated with cardiac hypertrophy, ventricular dilation, and systolic function.
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