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The aim is to identify genetic markers associated with blood pressure and cardiac mass in specific rat strains.

Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.

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The aim is to identify genetic markers associated with blood pressure and cardiac mass in specific rat strains.
Genome scanning of HXB and BXH recombinant inbred rat strains using 500 genetic markers.
Correlation of markers with left ventricular mass and arterial pressures.
Investigation of specific genetic markers on different chromosomes.
Drd1a on chromosome 17 shows the strongest correlation with left ventricular weight (P = .00038, r = -0.59).
D19Mit7 on chromosome 19 correlates with systolic pressure (P = .0012, r = .55).
Markers D2N35 on chromosome 2 (P = .0008, r = .56) and Il6 on chromosome 4 (P = .0018, r = .53) correlate with other arterial pressures.

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Randomized trial maps quantitative trait loci for cardiac mass and blood pressure in rat strains, indicating novel genetic control pathways.

Pravenec et al. (1995) studied this question.

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Randomized trial maps quantitative trait loci for cardiac mass and blood pressure in rat strains, indicating novel genetic control pathways.