Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

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Population

F2 population [F2] derived from a cross of the Dahl salt-sensitive rat and the Lewis rat

Design

Preclinical

Authors

Discussion

Does not guide hypertension management; leaves open translation of these rat QTLs to human disease.

Population

F2 population [F2(S x LEW)] derived from a cross of the Dahl salt-sensitive (S) rat and the Lewis (LEW/NCrlBR) (LEW) rat

Intervention

Genetic mapping of endothelin system genes

Outcome

Cosegregation with systolic blood pressuresurrogate

Identified two new quantitative trait loci for blood pressure in rats, marked by the ET2 locus on chromosome 5 and the HITH locus on chromosome 17.

Deng et al. (1994) studied this question.

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