December 1, 1996Hypertension
Analysis of Quantitative Trait Loci for Blood Pressure on Rat Chromosomes 2 and 13
Population
F2 rats derived from a cross of the spontaneously hypertensive rat and the Wistar-Kyoto rat
Design
Preclinical
Follow-up
12 to 25 weeks of age
Authors
Discussion
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Member takes
Implication
These rat QTLs warrant human genetic follow-up; leaves open translation to hypertension therapy.
Structured PICO
P
Population
F2 rats derived from a cross of the spontaneously hypertensive rat and the Wistar-Kyoto rat
I
Intervention
Mapping of quantitative trait loci (QTLs) on chromosomes 2 and 13
O
Outcome
Blood pressure measured longitudinally between 12 and 25 weeks of agesurrogate
Identified significant quantitative trait loci for blood pressure on rat chromosomes 2 and 13, highlighting age-dependent effects on chromosome 13.
Cite This Study
Samani et al. (1996) studied this question.