Population
Genetically Hypertensive rats and hypertension resistant Brown Norway rats, specifically single and combined…
Comparison
Transferring quantitative trait loci for blood… vs Parental strains (GH and BN)
Design
Preclinical
Authors
Loading...
QTL transfer alone fails to induce hypertension in rats; leaves open polygenic background effects on baroreflex and ANGII pathways.
Transferring hypertensive QTLs into a resistant background did not cause hypertension but altered baroreceptor sensitivity and ANGII response, suggesting genome background-dependent effects and intermediate phenotypes.
Bilušić et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: