Key result
High cardiovascular health (Life's Essential 8) was associated with lower CVD mortality in individuals with high polygenic risk scores compared to low cardiovascular health (HR 0.26; 95% CI 0.18-0.39).
Why the study?
To evaluate the independent, mediating, interactive, and associated effects of Life's Essential 8 and genetic predisposition on cardiovascular outcomes and all-cause mortality.
Does moderate or high cardiovascular health (based on Life's Essential 8) reduce the risk of cardiovascular outcomes and all-cause mortality across different genetic risk profiles?
Population
254 783 individuals from the UK Biobank
Comparison
Moderate or high vs low CVH across genetic predisposition categories
Design
National prospective cohort study
Follow-up
Median of 12.53 years
Authors
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May mitigate genetic CVD risk; leaves open causality and practice change pending trials.
Cohort (n=254,783)
Yes
Does moderate or high cardiovascular health (based on Life's Essential 8) reduce the risk of cardiovascular outcomes and all-cause mortality across different genetic risk profiles?
Hazard Ratio: 0.26 (95% CI 0.18–0.39)
Adherence to Life's Essential 8 guidelines is associated with significantly lower risks of cardiovascular and all-cause mortality, particularly mitigating risk in individuals with high genetic predisposition for CVD.
Zhang et al. (2023) conducted a cohort in Cardiovascular outcomes and all-cause mortality (n=254,783). High cardiovascular health (Life's Essential 8) vs. Low cardiovascular health was evaluated on CVD mortality in high polygenic risk score (PRS) group (HR 0.26, 95% CI 0.18-0.39). High cardiovascular health (Life's Essential 8) was associated with lower CVD mortality in individuals with high polygenic risk scores compared to low cardiovascular health (HR 0.26; 95% CI 0.18-0.39).
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