Key result
Aging links to declining infra-renal aortic failure stress and stretch driven by medial property loss.
Why the study?
Little information existed regarding layer-specific failure properties of the adult human abdominal aorta, and postfailure damage had not been quantified.
Comparison
Intact-wall strips vs individual aortic layer strips
Design
Ex vivo biomechanical autopsy study
Authors
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Intact-wall failure stress approximates key layer values; leaves open layer-specific modeling and postfailure quantification for aortic biomechanics.
Observational (n=47)
Biomechanical testing of human infra-renal aortas reveals that aging and cardiovascular risk factors adversely affect layer-specific failure stretches and increase stiffness.
Dimitrios P. Sokolis (2023) conducted an observational in Aortic aging and biomechanical properties (n=47). Aging was evaluated on Intact-wall failure stress and stretch. Intact-wall failure stress and stretch of the human infra-renal aorta declined from 20 to 60 years due to steady declines in medial properties, with postfailure stretch positively correlating with age.
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