Key result
Myocardial elastography demonstrated that all strains decreased at the acute MI stage but recovered to baseline at the remodeling stage, while strain rates remained low throughout recovery.
Why the study?
Traditional ECG diagnosis correlates poorly with the degree of MI, and using myocardial elastography to understand myocardial motion dysfunction and recovery may inform diagnosis and treatment.
Can myocardial elastography evaluate the evolution of strains and strain rates in canine myocardium after myocardial infarction?
Can myocardial elastography evaluate the evolution of strains and strain rates in canine myocardium after myocardial infarction?
Myocardial elastography can track the evolution of myocardial strains and strain rates, informing the recovery stages and location of dysfunction following acute MI in a canine model.
May enhance post-MI recovery monitoring in canines; extends elastography validation toward human translation.
Myocardial infarction (MI) is caused by occlusion of the coronary artery and can rapidly lead to death, 36% of patients die within 1 month of their first MI. Traditional ECG diagnosis has shown a poor correlation to the degree of MI. Understanding the dysfunction and recovery in myocardial motion following MI using myocardial elastography (ME) may inform future diagnosis and treatment for MI. Ten mongrel canines underwent a ligation procedure at the proximal LAD site for inducing infarction in the papillary and apical levels of the hearts. Transthoracic ultrasound images were taken before and up to 31 days after the ligation procedure. Strain and structural parameters including maximum principal strain (E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> ) and maximum shear strain (G <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> ), radial strain (E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rr</inf> ), circumferential strain (E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">θθ</inf> ), and their strain rates were measured. Territorial differences in strains were also compared. Strain and strain rates in LAD of the apical level were most affected after MI (Fig 3). All strains decreased at the acute MI stage but recovered to the baseline level at the remodeling stage. E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">θθ</inf> rate also recovered at the remodeling stage after decreasing in magnitude at the acute stage. However, G <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> , E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> and E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rr</inf> rates decreased after MI and remained low throughout the stages of recovery. Territorial strain and strain rates were able to inform the recovery stages as well as the location of dysfunction following MI. This study showed that ME could inform the diagnosis and treatment progression of acute MI.
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Ling et al. (2022) studied Myocardial infarction (n=10). Myocardial elastography vs. Baseline (before ligation) was evaluated on Evolution of strains and strain rates. Myocardial elastography demonstrated that all strains decreased at the acute MI stage but recovered to baseline at the remodeling stage, while strain rates remained low throughout recovery.
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