March 24, 2007AJP Heart and Circulatory Physiology
Acute myocardial infarction in mice: assessment of transmurality by strain rate imaging
Key result
Systolic strain rate imaging was significantly correlated with transmural extension of myocardial infarction (r = 0.89, P < 0.01) and was superior to conventional echocardiography in a murine model.
Why the study?
Does systolic strain rate imaging accurately predict the transmural extension of myocardial infarction in a murine model of acute MI?
Population
40 wild-type mice (C57BL/6, 2 months old)
Comparison
Acute myocardial infarction induced by 30, 60… vs Sham-treated group (n=10)
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Implication
Strain rate imaging may aid preclinical infarct assessment in mice; leaves open clinical translation and human validation.
Key Points
- This study assesses the efficacy of strain rate imaging in quantifying transmural extension of myocardial infarction in mice.
- Evaluated systolic strain rate in a murine model of acute myocardial infarction induced by varying durations of ischemia.
- Used echocardiography to assess left ventricular function in groups of wild-type mice after 24 hours of reperfusion.
- Measured area at risk and infarct size using triphenyltetrazolium chloride staining.
- Infarct size increased with ischemia duration (25% for 30 min, 56% for 60 min, 71% for 90 min; P < 0.05).
- Systolic strain rate decreased significantly with ischemia duration (from 13 to -2 s(-1); P < 0.05) and correlated with transmural extension (r = 0.89, P < 0.01).
- Systolic strain rate was identified as the most accurate predictor of transmurality using ROC curves.
Structured PICO
Does systolic strain rate imaging accurately predict the transmural extension of myocardial infarction in a murine model of acute MI?
P
Population
40 wild-type mice (C57BL/6, 2 months old) subjected to varying durations of left coronary artery occlusion or sham treatment.
E
Exposure
Acute myocardial infarction induced by 30, 60, or 90 minutes of left coronary artery occlusion followed by 24 hours of reperfusion, assessed by systolic strain rate (SR) imaging
C
Comparator
Sham-treated group (n=10)
O
Outcome
Transmural extension of myocardial infarction (TEI) and its correlation with systolic strain ratesurrogate
Main Result
Effect estimate: r = 0.89
p-value: p=<0.01
In a murine model of acute MI, systolic strain rate imaging is superior to conventional echocardiography for predicting the transmural extension of myocardial infarction early after reperfusion.
Cite This Study
Thibault et al. (2007) studied Acute myocardial infarction (n=40). Systolic strain rate (SR) imaging vs. Conventional echocardiography was evaluated on Transmural extension of myocardial infarction (TEI) (r = 0.89, p=<0.01). Systolic strain rate imaging was significantly correlated with transmural extension of myocardial infarction (r = 0.89, P < 0.01) and was superior to conventional echocardiography in a murine model.