Key result
In intact mice, 60 minutes of coronary occlusion caused a significant reduction in LVEF (from 70% to 37%, P<0.05) and depressed wall thickening in both infarcted and remote regions at 24 hours.
Why the study?
Does contrast-enhanced cardiac MRI accurately assess infarct size and cardiac function in intact mice early after reperfused myocardial infarction?
Population
23 intact mice (n=15 MI group, n=8 sham group)
Comparison
60 minutes of coronary occlusion followed by… vs Thoracotomy without occlusion (sham group)
Design
Preclinical
Follow-up
24 hours
Authors
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Enables serial noninvasive infarct assessment in murine MI models; leaves open translation to clinical imaging.
Does contrast-enhanced cardiac MRI accurately assess infarct size and cardiac function in intact mice early after reperfused myocardial infarction?
p-value: p=<0.05
Contrast-enhanced cardiac MRI can accurately assess infarct size and cardiac function in intact mice early after reperfused MI, revealing contractile dysfunction in noninfarcted regions.
Yang et al. (2004) studied Myocardial infarction (n=23). 60 minutes of coronary occlusion vs. Thoracotomy without occlusion (sham) was evaluated on Left ventricular ejection fraction (LVEF) at 24 hours (p=<0.05). In intact mice, 60 minutes of coronary occlusion caused a significant reduction in LVEF (from 70% to 37%, P<0.05) and depressed wall thickening in both infarcted and remote regions at 24 hours.
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