July 1, 2008Investigative Radiology

Longitudinal Follow-up of Cardiac Structure and Functional Changes in an Infarct Mouse Model Using Retrospectively Gated Micro-Computed Tomography

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Why the study?

Does retrospectively gated micro-CT accurately measure longitudinal cardiac structural and functional changes in an infarct mouse model?

Population

13 male C57BL/6 mice (7 sham-operated, 6 infarcted via left anterior descending coronary artery ligation)

Comparison

Retrospectively gated micro-computed tomography… vs Sham-operated mice and Millar pressure…

Design

Preclinical

Follow-up

4 weeks

Authors

SDSarah A. DetombeWestern University NFNancy L. FordUniversity of British Columbia FXFu-Li XiangNational Sun Yat-sen University

Discussion

Member takes

Implication

Enables longitudinal cardiac phenotyping in mouse MI models; leaves open translation to clinical imaging.

Structured PICO

Does retrospectively gated micro-CT accurately measure longitudinal cardiac structural and functional changes in an infarct mouse model?

Population

13 male C57BL/6 mice (7 sham-operated, 6 infarcted via left anterior descending coronary artery ligation)

Intervention

Retrospectively gated micro-computed tomography (micro-CT) imaging using an iodinated blood-pool contrast agent (0.01 mL/g Fenestra VC) at baseline and weeks 1, 2, 3, and 4 post-ligation

Comparator

Sham-operated mice (for disease model comparison) and Millar pressure conductance catheter hemodynamic measurements at week 4 (for technique validation)

Outcome

Cardiac function parameters including systolic and diastolic volumes, and ejection fraction, as well as comparison of ejection fraction derived from CT versus hemodynamic measurementssurrogate

Retrospectively gated micro-CT is a feasible and accurate noninvasive tool for longitudinally tracking cardiac remodeling in mouse models of myocardial infarction.

Cite This Study

Detombe et al. (2008) studied this question.

synapsesocial.com/papers/6a6fc98726a7f98052dc634b https://doi.org/10.1097/rli.0b013e3181727519

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Longitudinal Follow-up of Cardiac Structure and Functional Changes in an Infarct Mouse Model Using Retrospectively Gated Micro-Computed Tomography

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Longitudinal Follow-up of Cardiac Structure and Functional Changes in an Infarct Mouse Model Using Retrospectively Gated Micro-Computed Tomography

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider