High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT
Why the study?
Does delayed-enhancement cine micro-CT accurately quantify myocardial infarct size compared to ex vivo TTC staining in experimental mouse models of MI?
Population
20 mice subjected to surgical ligation of the left coronary artery or sham surgery (n=6 or 7 per group)
Comparison
Delayed-enhancement cine micro-computed… vs Ex vivo staining with triphenyltetrazolium…
Design
Preclinical
Follow-up
5 or 35 days post-surgery
Authors
Discussion
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Member takes
Implication
Validates micro-CT for serial infarct sizing in mouse MI models; leaves open translation to clinical imaging.
Structured PICO
Does delayed-enhancement cine micro-CT accurately quantify myocardial infarct size compared to ex vivo TTC staining in experimental mouse models of MI?
P
Population
20 mice subjected to surgical ligation of the left coronary artery or sham surgery (n=6 or 7 per group)
I
Intervention
Delayed-enhancement cine micro-computed tomography (microCT) imaging with a high-molecular-weight blood pool CT agent and continuous infusion of iopamidol 370
C
Comparator
Ex vivo staining with triphenyltetrazolium chloride (TTC)
O
Outcome
Agreement of in vivo CT determination of infarct size at the midventricular level with ex vivo TTC stainingsurrogate
Delayed-enhancement cine micro-CT provides a reliable and rapid method to quantify infarct size and assess cardiac remodeling in murine models of myocardial infarction.
Cite This Study
Nahrendorf et al. (2007) studied this question.