Key result
In Korean patients with bicuspid aortic valve, aortic stenosis was the predominant cause of surgery in those aged ≥50 years (87%), while aortic regurgitation (46%) and infective endocarditis (19%) were more common in younger patients.
Why the study?
What are the clinical characteristics, surgical indications, and echocardiographic phenotypes of Korean patients with bicuspid aortic valve undergoing aortic valve surgery?
Observational (n=1,160)
Yes
What are the clinical characteristics, surgical indications, and echocardiographic phenotypes of Korean patients with bicuspid aortic valve undergoing aortic valve surgery?
In Korean patients with bicuspid aortic valve, surgical indications vary significantly by age, with aortic stenosis dominating in older patients and aortic regurgitation/endocarditis being more common in younger patients.
Answers are grounded in this paper and cite their sources.
May inform age-based surgical planning in Korean bicuspid aortic valve; leaves open validation in prospective multi-ethnic cohorts.
BACKGROUND AND OBJECTIVES: Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS: Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A standard case report form was used for clinical and echocardiographic parameters. RESULTS: Mean age at the time of AV surgery was 59±13 years. The most common cause of AV surgery was aortic stenosis (AS, 892 [77%]), followed by aortic regurgitation (AR, 199 [17%]), and infective endocarditis (69 [6%]). AS showed a skewed peak in the aged population and was the predominant cause of AV surgery (87%) in patients ≥50 years of age, whereas AR (46%) and active infective endocarditis (19%) were more common in younger patients (p<0.001). Echocardiographic determination of the BAV phenotype revealed that fusion of the right coronary cusp (RCC) and left coronary cusp (LCC) was most common (622 [53%]), followed by fusion of RCC and non-coronary cusp (NCC) (313 [27%]), and fusion of LCC and NCC (42 [4%]); the BAV phenotype could not be determined in the remaining 183 patients (16%). Fusion of RCC and LCC was more commonly observed in patients with AR than in those with AS (74% vs. 49%; p<0.001). CONCLUSION: BAV patients were characterized by distinct surgical indications according to their age. Possible associations between BAV phenotypes and surgical indications with potential impacts of ethnicity need to be tested in further studies.
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Sun et al. (2017) conducted an observational in Bicuspid aortic valve requiring aortic valve surgery (n=1,160). Bicuspid aortic valve was evaluated on Dominant valvular pathology for aortic valve surgery (p=<0.001). In Korean patients with bicuspid aortic valve, aortic stenosis was the predominant cause of surgery in those aged ≥50 years (87%), while aortic regurgitation (46%) and infective endocarditis (19%) were more common in younger patients.
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