Key result
High and low hematocrit worsen carotid model hemodynamics by spreading low TAWSS and increasing OSI.
Why the study?
The effects of hematocrit levels on flow features and wall shear stress levels in large stenotic arteries are not well reported.
Do high and low hematocrit levels alter flow structures and wall shear stress in healthy and stenosed carotid arteries compared to normal hematocrit levels?
Population
Models of healthy and stenosed carotid arteries
Comparison
High (65%) and low (25%) Hct levels vs normal Hct level (45%)
Design
Computational simulation study
Authors
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Altered hematocrit may affect carotid hemodynamics in stenosis; leaves open need for clinical validation before risk stratification use.
Do high and low hematocrit levels alter flow structures and wall shear stress in healthy and stenosed carotid arteries compared to normal hematocrit levels?
Computational modeling demonstrates that both abnormally high and low hematocrit levels adversely alter hemodynamic features and wall shear stress in carotid arteries, potentially increasing the risk of plaque progression or rupture.
Khan et al. (2024) studied Healthy and stenosed carotid arteries. High (65%) and low (25%) hematocrit levels vs. Normal hematocrit level (45%) was evaluated on Variation in axial and secondary flow characteristics, vortex structures, and WSS-based parameters. High (65%) and low (25%) hematocrit levels adversely affected hemodynamics in carotid artery models, with low hematocrit spreading low TAWSS and high hematocrit increasing OSI.
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